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Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators

Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis. Mouse studies showed that killer T cells were activated and turned into cells that recognize nerve-coating proteins by Tip-dendritic cells. With probing, tentacle-like membrane protrusions, these instigators arise from inflammatory white blood cells. Conversely, the activated T cells might at times protect against MS. The researchers are seeking specific immunotherapies for MS that avoid side effects of general immunosuppressants.
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