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Novel combination therapy shuts down escape route, killing glioblastoma tumor cells

Scientists have uncovered an unexpected, but important molecular mechanism of mTOR inhibitor resistance and a novel drug combination that reverses this resistance using low dose arsenic in mice. The mTOR pathway is hyperactivated in 90 percent of glioblastomas, the most lethal brain cancer in adults. The data suggest a new approach for treatment of glioblastoma.
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