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Cocaine, pleasure principle explored in new rat study

On the other side of the cocaine high is the cocaine crash, and understanding how one follows the other can provide insight into the physiological effects of drug abuse. For decades, brain research has focused on the pleasurable effects of cocaine largely by studying the dopamine pathway. But this approach has left many questions unanswered. The findings of the new study suggest that the same neural mechanism responsible for the negative effects of cocaine likely contribute to the animal's decision to ingest cocaine.
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