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Higher levels of cerebrospinal fluid predict faster cognitive loss in Parkinson's disease

A characteristic pathological feature of Parkinson's disease (PD) is the presence of Lewy bodies, which are formed by intracellular deposits of the protein ?-synuclein in neurons. Although several large studies have examined ?-synuclein levels in the cerebrospinal fluid of PD patients, its role in cognitive decline and dementia had been unexplored. Now, counterintuitive findings offer new insights into PD pathology.
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