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Obesity, diabetes pre-programmed in womb? Fetal response to glucose associated with mother's insulin sensitivity

Direct evidence has been shown that fetal brain response to a dose of sugar given orally to its mother is associated with the mother's insulin sensitivity. This may indicate that the risk of subsequent obesity and diabetes may be pre-programmed in the womb. The authors conclude: "Lower maternal insulin sensitivity is associated with slower fetal brain responses. These findings provide the first evidence of a direct effect of maternal metabolism on fetal brain activity and suggest that central insulin resistance may be programmed during fetal development."
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