Too much protein may kill brain cells as Parkinson's progresses
The most common genetic cause of Parkinson's disease destroys brain cells and devastates many patients worldwide, scientists have discovered. The investigators found that mutations in a gene called leucine-rich repeat kinase 2 may increase the rate at which LRRK2 tags ribosomal proteins, which are key components of protein-making machinery inside cells. This could cause the machinery to manufacture too many proteins, leading to cell death.
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