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Novel mechanism for neurological disorder unraveled by international team

A novel gene (CLP1) associated with a neurological disorder affecting both the peripheral and central nervous systems has been discovered by an international team of researchers. They show that disturbance of a very basic biological process, tRNA biogenesis, can result in cell death of neural progenitor cells. This leads to abnormal brain development and a small head circumference as well as dysfunction of peripheral nerves.
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