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Testing Parkinson's disease immune-based drugs: New models

Using powerful, newly developed cell culture and mouse models of sporadic Parkinson?s disease (PD), researchers have demonstrated that immunotherapy with specifically targeted antibodies may block the development and spread of PD pathology in the brain. By intercepting the distorted and misfolded alpha-synuclein (?-syn) proteins that enter and propagate in neurons, creating aggregates, the researchers prevented the development of pathology and also reversed some of the effects of already-existing disease.
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