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Can injuries to the skin be painless?

Lesions in patients with Buruli ulcer, a tropical disease, have been the focus of recent study. Investigators show that, despite the extent and severity of these wounds, they are less painful than others that seem relatively minor (e.g. scratches, low-degree burns). They discovered an analgesic mechanism that limits the transmission of pain signals to the brain that may be useful in developing new drugs for pain relief.
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