New cellular garbage control pathway with relevance for human neurodegenerative diseases
Several human neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's disease, are linked to an accumulation of abnormal and aggregated proteins in cells. Cellular 'garbage' can be removed from cells by sweeping them to a cellular recycling station known as the lysosome. Scientists have now discovered a new family of helper proteins that recognize labeled protein waste and guide them efficiently to the lysosome for destruction and recycling.
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